A FRAMEWORK FOR THE DESIGN, CONDUCT AND INTERPRETATION OF RANDOMISED CONTROLLED TRIALS IN THE PRESENCE OF TREATMENT CHANGES

Abstract Background When a randomised trial is subject to deviations from randomised treatment, analysis according to intention-to-treat does not estimate two important quantities: relative treatment efficacy and effectiveness in a setting different from that in the trial.Even in trials of a predominantly pragmatic nature, there may be numerous rea

The paper is part of the publication series, which describe the most significant and innovative research and development design solutions and computational procedures as part of European structural funds project.The object of this article is strength conditions assessment of new structure of a&d ej-123 rail bogie frame, which is characterized mainl